Product Overview
IGF-1 LR3 1mg (Insulin-like Growth Factor-1 Long Arg3) is a synthetic, recombinant analogue of endogenous IGF-1. This 83-amino acid polypeptide is specifically engineered for advanced laboratory research. The "LR3" modification—substituting Arginine for Glutamic Acid at position 3 and adding a 13-amino acid extension at the N-terminus—results in a compound with significantly higher biological potency.
Supplied as a 1mg lyophilized (freeze-dried) powder, IGF-1 LR3 is a primary tool for investigating cellular growth signaling, protein synthesis, and receptor-mediated biochemical pathways. Its unique structure prevents binding to IGF-binding proteins (IGFBPs), allowing for increased bioavailability and a prolonged half-life in experimental models.
Mechanism of Action: IGF-1 Receptor Agonism
IGF-1 LR3 acts as a highly potent agonist of the IGF-1 Receptor (IGF-1R). In controlled research settings, its primary mechanisms include:
- IGFBP Evasion: Studying how the LR3 modification bypasses inhibitory binding proteins, leading to sustained activation of the IGF-1R.
- PI3K/Akt Pathway Activation: Investigating the downstream signaling that triggers cellular proliferation and inhibits apoptosis (programmed cell death).
- Enhanced Myogenesis: Analyzing the differentiation and proliferation of myoblasts (muscle precursor cells).
- Glucose & Amino Acid Uptake: Researching the insulin-mimetic effects of IGF-1 LR3 on nutrient transport into cellular tissues.
Primary Research Applications & Studied Effects
Our IGF-1 LR3 1mg preparation is frequently utilized in preclinical studies focusing on:
- Protein Synthesis & Muscle Repair Research
IGF-1 LR3 is widely studied for its role in accelerating muscle protein synthesis and promoting the regeneration of damaged muscle fibers. Researchers investigate its efficacy in modeling recovery from intense physical strain or simulated injury. - Metabolic Health & Fat Oxidation in laboratory models, this peptide is explored for its ability to regulate fat storage and promote the utilization of fatty acids for energy production, contributing to shifts in body composition and lean mass preservation.
- Connective Tissue & Osteoblast Activity by stimulating collagen synthesis, IGF-1 LR3 is used to research the repair of tendons and ligaments. It is also a subject of interest in bone remodeling studies, particularly regarding age-related bone density loss.
- Longevity & Anti-Aging Potential as a mediator of growth hormone (GH) effects, IGF-1 LR3 is investigated for its role in systemic tissue repair and the maintenance of youthful cellular function.
Research Applications Summary
In controlled laboratory environments, IGF-1 LR3 is utilized for:
- Cell Signaling Pathway Investigation: Mapping the Akt/mTOR signaling axis.
- Growth Factor Receptor Research: Probing the kinetics of IGF-1R binding.
- Intracellular Signaling Network Analysis: Modeling metabolic and regulatory systems.
- Comparative Biochemical Modeling: Benchmarking LR3 against standard IGF-1 or IGF-1 DES.
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