Product Overview
MOTS-c 40mg is a high-purity, synthetic peptide derived from the mitochondrial DNA (mtDNA). As a member of the Mitochondrial-Derived Peptide (MDP) family, MOTS-c is a primary subject in advanced research regarding cellular metabolic regulation, energy homeostasis, and mitochondrial signaling pathways.
Supplied as a 40mg lyophilized (freeze-dried) powder, this research-grade peptide is engineered for maximum stability. It is widely investigated for its "exercise mimetic" properties, specifically its ability to activate the AMPK pathway and influence systemic glucose utilization and metabolic flexibility.
Mechanism of Action: The Mitochondrial Signaling Pathway
MOTS-c is unique because it is encoded within the 12S rRNA gene of the mitochondrial genome. In laboratory settings, researchers study its function as a nuclear-signaling peptide that relocates to the nucleus in response to metabolic stress.
Research Applications
In controlled laboratory environments, MOTS-c is utilized for:
- Mitochondrial Signaling Investigations: Mapping the intracellular regulatory networks.
- Metabolic Flexibility Modeling: Studying fuel-source switching in skeletal muscle.
- MDP Comparative Research: Benchmarking MOTS-c against other mitochondrial peptides like Humanin.
- Adaptive Stress Response Studies: Exploring cellular resilience to metabolic deprivation.
Key Areas of Metabolic & Longevity Research
- AMPK Activation: Investigating how MOTS-c triggers the AMP-activated protein kinase (AMPK) pathway to promote energy balance.
- Glucose & Lipid Metabolism: Studying its role in enhancing glucose uptake in skeletal muscle and promoting fatty acid oxidation (fat burning).
- Mitochondrial Homeostasis: Analyzing how MOTS-c optimizes the function of cellular "powerhouses" and enhances resilience to environmental stressors.
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